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Abstract from PubMed in separate window Carbon monoxide combined with artificial blood cells acts as an antioxidant for tissues thermally-damaged by dye laser irradiation

Rikihisa N1, Shimanouchi K2, Saito Y, Sakai H3, Mitsukawa N4
Burns, 2022 Mar 19; S0305-4179(22)00063-8. doi: 10.1016/j.burns.2022.03.009.
1 Oyumino Central Hospital
2 Department of Plastic, Reconstructive, and Aesthetic Surgery, Chiba University Hospital
3 Department of Chemistry, Nara Medical University
4 Department of Plastic, Reconstructive Surgery, Chiba University Graduate School of Medicine

Abstract from PubMed in separate window Possible effects of voluntary exercise intensity on anxiety-like behavior and its underlying molecular mechanisms in the hippocampus: Results from a study in Hatano rats

Asano H1, Moriya S2, Hatakeyama T1,3, Kobayashi S1,3, Akimoto T1, Ohta R, Kawaguchi M1
Behav. Brain Res., 2022 Jun 3: 427:113854. doi: 10.1016/j.bbr.2022.113854. Epub 2022 Mar 19.
1 Lab of Animal Behavior and Environmental Science, School of Agriculture, Meiji University
2 Department of Biochemistry and Genetics, Chiba University Graduate School of Medicine
3 Organization for the Strategic Coordination of Research and Intellectual Property, Meiji University

Abstract from PubMed in separate window Artificial red blood cells increase large vessel wall damage and decrease surrounding dermal tissue damage in a rabbit auricle model after subsequent flashlamp-pumped pulsed-dye laser treatment

Shimanouchi K1, Rikihisa N2, Saito Y, Iuchi K3, Tsumura N3, Sakai H4, Mitsukawa N5
J. Dermatol., (2021): 48(5), 600-612. doi: 10.1111/1346-8138.15805. Epub 2021 Feb 25.
1 Department of Plastic, Reconstructive, and Aesthetic Surgery, Chiba University Hospital
2 Oyumino Central Hospital
3 Department of Imaging Sciences, Chiba University
4 Department of Chemistry, Nara Medical University
5 Department of Plastic, Reconstructive, and Aesthetic Surgery, Chiba University Graduate School of Medicine

Abstract from PubMed in separate window Rapeseed (canola) oil aggravates metabolic syndrome-like conditions in male but not in female stroke-prone spontaneously hypertensive rats (SHRSP)

Nishikawa M1, Ohara N1, Naito Y2, Saito Y, Amma C1, Tatematsu K3, Baoyindugurong J4, Miyazawa D1, Hashimoto Y5, Okuyama H1
Toxicol. Rep. 2022 Feb 7;9:256-268. doi: 10.1016/j.toxrep.2022.01.011. eCollection 2022.
1College of Pharmacy, Kinjo Gakuin University
2School of Allied Health Sciences, Kitasato University
3Gifu Pharmaceutical University
4College of Food Science and Engineering, Inner Mongolia Agricultural University
5School of Dentistry, Aichi-Gakuin University

Abstract from J-STAGE in separate window Dietary rapeseed (canola) oil suppresses testosterone production and increases plasma aldosterone level in stroke-prone spontaneously hypertensive rats (SHRSP)

Nishikawa M1, Ohara N1, Naito Y2, Amma C1, Saito Y, Tatematsu K3, Baoyindugurong J4, Miyazawa D1, Hashimoto Y5, Okuyama H1
Fundam. Toxicol. Sci., (2022): 9, 7-16
1College of Pharmacy, Kinjo Gakuin University
2School of Allied Health Sciences, Kitasato University
3Gifu Pharmaceutical University
4College of Food Science and Engineering, Inner Mongolia Agricultural University
5School of Dentistry, Aichi-Gakuin University

 皮膚感作性試験代替法 Interleukin-8 Reporter Gene Assay(IL-8 Luc assay)評価報告書

小島幸一, 足利太可雄1, 安達玲子1, 佐藤一博2, 瀬崎拓人3, 武吉正博4, 福山朋季5
AATEX-JaCVAM, (2021): 10(1), 49-68
1国立医薬品食品衛生研究所
2国立大学法人 福井大学
3三井化学株式会社
4一般財団法人 化学物質評価研究機構
5麻布大学

Abstract from PubMed in separate window Effect of tris(1,3-dichloro-2-propyl) phosphate on epididymal sperm parameters in adult male rats

Kobayashi S1,2, Kawano N3, Miyado K4, Ohta R, Akimoto T2, Hatakeyama T1,2, Kawaguchi M2
J. Vet. Med. Sci., (2022): 84, 153-156
1Organization for the Strategic Coordination of Research and Intellectual Property, Meiji University
2Lab of Animal Behavior and Environmental Science, School of Agriculture, Meiji University
3Lab of Regulatory Biology, School of Agriculture, Meiji University
4Department of Reproductive Biology, National Research Institute for Child Health and Development

Abstract from PubMed in separate window Alterations between high and low-avoidance lines of Hatano ratsin learning behaviors, ultrasonic vocalizations, and histlogical characteristics in hippocampus and amygdala

Chiba S1, Okawara T2, Kawakami K2, Ohta R, Kawaguchi M2
Physiol. Behav., 2022 Mar 1;245:113670. doi: 10.1016/j.physbeh.2021.113670.
1Faculty of Veterinary Medicine, Okayama University of Science
2School of Agriculture, Meiji University

Abstract from PubMed in separate window Within- and between-laboratory reproducibility and predictive capacity of amino acid derivative reactivity assay (ADRA) using a 0.5 mg/mL test chemical solution: Results of the study for reproducibility confirmation implemented in five participating laboratories

Yamamoto Y1, Fujita M1, Watanabe S2, Yamaga H2, Wakabayashi K3, Tahara Y3, Horie N4, Fujimoto K4, Takeuchi K5, Kamiya K5, Kawakami T6, Kojima K, Sozu T7, Kojima H8, Kasahara T1, Ono A9
J Appl Toxicol, (2022): 42, 1078-1090
1Safety Evaluation Center, Fujifilm Corporation
2Safety Science Research Laboratories, Lion Corporation
3Chemical Safety Department, Mitsui Chemicals, Inc.
4Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd.
5Biological Research Laboratories, Nissan Chemical Corporation
6Division of Environmental Chemistry, National Institute of Health Sciences
7Faculty of Engineering, Tokyo University of Science
8Biological safety Research Center, Division of Risk Assessment, National Institute of Health Sciences
9Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Division of Pharmaceutical Sciences, Okayama University

Abstract from PubMed in separate window The within- and between-laboratories reproducibility and predictive capacity of Amino acid Derivative Reactivity Assay using 4 mM test chemical solution: Results of ring study implemented at five participating laboratories

Fujita M1, Yamamoto Y1, Wanibuchi S1, Watanabe S2, Yamaga H2, Wakabayashi K3, Tahara Y3, Horie N4, Fujimoto K4, Takeuchi K5, Kamiya K5, Kawakami T6, Kojima K, Sozu T7, Kojima H8, Kasahara T1, Ono A9
J Appl Toxicol, (2022): 42, 318-333
1Safety Evaluation Center, Fujifilm Corporation
2Safety Science Research Laboratories, Lion Corporation
3Chemical Safety Department, Mitsui Chemicals, Inc.
4Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd.
5Biological Research Laboratories, Nissan Chemical Corporation
6Division of Environmental Chemistry, National Institute of Health Sciences
7Faculty of Engineering, Tokyo University of Science
8Biological safety Research Center, Division of Risk Assessment, National Institute of Health Sciences
9Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Division of Pharmaceutical Sciences, Okayama University

Abstract from PubMed in separate window Fully hydrogenated canola oil extends lifespan in stroke-prone spontaneously hypertensive rats

Tatematsu K1, Miyazawa D2, Saito Y, Okuyama H2, Ohara N2
Lipids Health Dis., (2021): 20, 102, https://doi.org/10.1186/s12944-021-01540-7
1Department of Radiochemistry, Gifu Pharmaceutical University
2Open Research Center for Lipid Nutrition, Kinjo Gakuin University College of Pharmacy

Abstract from J-STAGE in separate window Behavior of chemical respiratory sensitizers in in vitro methods for skin sensitization

Narita K, Okutomi H, Kawakami K, Sui H, Basketter D1, Ashikaga T2
AATEX, (2021): 26, 9-18
1DABMEB Consultancy Ltd.
2Division of risk assesment, National institute of heath sciences

食品中の栄養成分検査の技能試験 (2017-2018)

竹林純1、高坂典子、鈴木一平1、中阪聡亮、平林尚之、石見佳子1,2、梅垣敬三1,3、千葉剛1、渡辺卓穂
食品衛生学雑誌、Vol.61 (2)、pp.63-71
1 国立研究開発法人医薬基盤・健康・栄養研究所 国立健康・栄養研究所
2 東京農業大学 総合研究所
3 昭和女子大学 生活科学部 食安全マネジメント学科

Abstract from PubMed in separate window Novel toxicity of tris(1,3-dichloro-2-propyl) phosphate in adult male rats

Kobayashi S1,2, Abe K2, Isobe A2, Nakayama A2, Akimoto T2, Hatakeyama T1,2, Saito Y, Yanagisawa R3, Koike E3, Suzuki N3, Kawaguchi M2, Ohta R
J Appl Toxicol, (2021) 41(6), 987-992
1Organization for the Strategic Coordination of Research and Intellectual Property, Meiji University
2Lab of Animal Behavior and Environmental Science, School of Agriculture, Meiji University
3Center for Health and Environmental Risk Research, National Institute for Environmental Studies

医療機器の生物学的安全性試験

小島幸一
安全性試験の教育・研修テキスト
Vol.6、pp395-456

皮膚感作性試験代替法:ARE-Nrf2 luciferase LuSens Test Method

小島幸一、足利太可雄1、安達玲子1、佐藤一博2、瀬崎拓人3、武吉正博4、福山朋季5
AATEX-JaCVAM, (2020) 9(1), 43-57
1国立医薬品食品衛生研究所
2国立大学法人 福井大学
3三井化学株式会社
4一般財団法人 化学物質評価研究機構
5麻布大学

Abstract from PubMed in separate window Maternal traits during lactation period reduce the anxiety-related behavior in male offspring:Results from a fostering study in Hatano rats

Horii Y1, Nakajima S1, Akieda-Asai S2, Ohta R, Kawaguchi R1
Physiol. Behav., (2021) Feb 1;229:113209.
1School of Agriculture, Meiji University
2Frontier Science Research Center, University of Miyazaki

  
Abstract from PubMed in separate window The within- and between-laboratory reproducibility and predictive capacity of the in chemico amino acid derivative reactivity assay: Results of validation study implemented in four participating laboratories

Fujita M1, Yamamoto Y1, Watanabe S2, Sugawara T2, Wakabayashi K3, Tahara Y3, Horie N4, Fujimoto K4, Kusakari K5, Kurokawa Y5, Kawakami 66, Kojima K, Sozu T7, Nakayama T7, Kusao T7, Richmond J8, Nicole K9, Kim BH10, Kojima H11, Kasahara T1, Ono A12
J Appl Toxicol (2019): 39(11):1492-1505. doi: 10.1002/jat.3834. Epub 2019 Jul 17.
1Safety Evaluation Center, Fujifilm Corporation
2Human & Environmental Safety Evaluation Center, Lion Corporation
3Chemical Safety Department, Mitsui Chemicals, Inc.
4Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd.
5Biological Research Laboratories, Nissan Chemical Corporation
6Division of Environmental Chemistry, National Institute of Health Sciences
7Faculty of Engineering, Tokyo University of Science
8Dr. Jon Richmond: Advice and Consultancy
9NTP Interagency Center for the Evaluation of Alternative Toxicological Methods
10College of Natural Sciences Keimyung University
11Biological Safety Research Center, Division of Risk Assessment, National Institute of Health Sciences
12Graduate School of Medicine, Dentistry and Pharmaceutical sciences, Division of Pharmaceutical Sciences, Okayama University

  
Abstract from PubMed in separate window Multi-laboratory validation study of the vitrigel-eye irritancy test method as an alternative to in vivo eye irritation testing

Kojima H1, Yamaguchi H2, Sozu T3, Kleinstreuer N4, Chae-Hyung L5, Chen W6, Watanabe M, Fukuda T7,Yamashita K8, Takezawa T9
ATLA, (2019): 47, 140–157
1Japanese Center for the Validation of Alternative Methods (JaCVAM), National Institute of Health Sciences (NIHS), Kawasaki, Kanagawa, Japan
2Kanto Chemical Co., Inc., Isehara, Kanagawa, Japan
3Tokyo University of Science, Katsushika-ku, Tokyo, Japan
4Research Division, Chugai Pharmaceutical Co., LTD. Committee on the Validation of Alternative Methods (ICCVAM), Research Triangle Park, NC, USA
5Korean Center for the Validation of Alternative Methods (KoCVAM), National Institute of Food and Drug Safety Evaluation, Osong-eup, Chungcheongbuk-do, South Korea
6Industrial Technology Research Institute, (ITRI), Hsinchu, Taiwan
7Bozo Research Center (BRC), Setagaya-ku, Tokyo, Japan
8Daicel Corporation (Daicel), Himeji, Hyogo, Japan
9Institute of Agrobiological Sciences (NIAS), National Agriculture and Food Research Organization (NARO), Tsukuba, Ibaraki, Japan


Abstract from PubMed in separate window Historical control data on developmental toxicity studies in rats

Kuwagata M, Sakai Y1, Tanaka S2, Takashima H3, Katagiri R4, Matsuoka T5, Noritake K6, Senuma M, Shimizu T7, Hojo H8, Ibi K9, Kudo S10, Oota T11, Ube M12, Miwa Y13, Kajita S14, Uesugi T15, Yabe K16, Tateishi T17, Nakano N18, Taniguchi T19, Yamashita A20, Hirano T21, Kirihata Y22, Sakai Y23, Nishizawa S27, Fujiwara M1, Mineshima H26, Horimoto M25, Ema M24
Congenit Anom Kyoto, (2019): 59, 125-131
1Drug Safety Research Labs., Astellas Pharma Inc.
2Public Interest Incorporated Foundation, Biosafety Research Center
3Toxicology Department, GotembaLaboratory, BoZo Research Center Inc.
4National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM)/Interagency Coordinating
5Medicinal Safety Research Laboratories, Daiichi Sankyo Co., Ltd.
6Tsukuba, Drug Safety Eisai Co., Ltd./Preclinical Safety Research Unit, Sunplanet Co., Ltd.
7Research administration Dept., Safety Research Center, Ina Research Inc.
8Laboratory of Reproductive and Developmental Toxicology, Toxicology Division, The Institute of Environmental Toxicology
9Pharmacokinetics and Safety Department Drug Research Center, Kaken Phamaceutical Co., Ltd.
10WATARASE Research Center, Kyorin Pharmaceutical Co., Ltd.
11LSI Medience Corporation
12Safety Research Laboratories, Mitsubishi Tanabe Pharma Corporation
13Nihon Bioresearch Inc.
14Safety Research Laboratories, Ono Pharmaceutical Co., Ltd.
15Department of Drug Safety Research Nonclinical Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.
16Safety Research Institute for Chemical Compounds Co., Ltd
17Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories(SNBL), Ltd.
18Drug Safety Evaluation, Research Laboratory for Development, Shionogi& Co., Ltd.
19Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd.
20Preclinical Reserch Unit, Sumitomo Dainippon Pharma Co., Ltd.
21Toxicology Laboratory, Taiho Pharmaceutical Co., Ltd.
22Taisho Phamaceutical Co., Ltd.
23Drug Safety Research Laboratories,Pharmaceutical Risearch Division, Takeda Phamaceutical Company, Ltd.
24Research Institute of Science for Safety and Sustainability, National Institute of Advanced Industorial Science and Technology(AIST)
25Faculty of risk and Crisis Management, Chiba Institute of Science
26Tsukuba Drug Safety, Eisai Co,, Ltd.
27Phamacology Research Department, Teijin Institutie for Biomedical Research, Teijin Pharma Limited


特例認定校卒業生として―実験動物技術者として原点―

村田龍介
LABI021, (2019): 78, pp 40


Abstract from Biocompatibility and Performance of Medical Devices in separate window Biological evaluation and regulation of medical devices in Japan

Kojima K, Sakaguchi K1
Biocompatibility and Performance of Medical Devices, (2019): Woodhead Publishing; Second Edition
1Terumo Co.


Abstract from J-STAGE in separate window Hatano rats selectively bred for high- and low-avoidance learning: an overview

Ohta R, Kojima K
Exp. Anim., (2019): 68, 127-136


Effect of essential oils contained linalool on skin sensitization using human cell line activation test

Doi M1, 2, Watanabe M, Ariumi H1, Yoshiyama Y1
AATEX, (2019): 23, 9-15
1Laboratory of Community Pharmacy, Division of Clinical Pharmacy, Research and Education Center for Clinical Pharmacy, School of Pharmacy, Kitasato University
2Medical System Network Corporation


Abstract from PubMed in separate window Method for combined observation of serial sections of stented arteries embedded in resin by light microscopy and transmission electron microscopy

Isobe A1, Iwatani K1, Souba J1, Terao H1, Hagiwara H1, Kumagai F, Saito Y, Nagano K2, Tasaki M1
Toxicol Pathol, (2019): 47 (3), 401-407
1Evaluation Center, R & D Administration and Promotion Department, Terumo Corporation
2Nagano Toxicologic-Pathology Consulting

Effects of pregnancy experience on ovarian senescence and longevity in Hatano rats bred for high- and low-avoidance learning

Ohta R, Ohmukai H
Exp. Gerontol., (2019): 117, 91-98


Enhancement of pesticide peak response in GC-MS in the presence of multiple co-existing reference pesticides

Yoshimitsu M1, Akutsu K1, Kitagawa Y1, Takatori S1、Fukui N1 Osakada M1, Yamaguchi S2, Namikawa M3, Ban S3, Okubo Y4, Nakashima R4, Maruyama R4, Kakutani N1, Miyamoto I1, Yamashita K5, Nishiyama T5, Shinto M6, Yamamoto N6, Takai Y7, Hinoshita K8, Kajimura K1, Obana H9, Watanabe T
Food Hyg. Saf. Sci., (2018): 59(3), 146-150
1Osaka Institute of Public Health
2Osaka Prefecture Fujiidera Public Health Center
3Kyoto City Institute of Health and Environmental Sciences
4Kobe Institute of Health
5Nara Prefectural Institute of Health
6Sakai City Institute of Public Health
7Wakayama Prefectural Research Center of Environment and Public Health
8Wakayama Prefecture Shingu Public Health Center Kushimoto Branch Office
9San-Ei Gen F.F.I., Inc.


Comparison of assigned values from participants' results, spiked concentrations of test samples, and isotope dilution mass spectrometric results in proficiency testing for pesticide residue analysis

Yarita T1, Otake T1, Aoyagi Y1, Takasaka N, Suzuki T, Watanabe T
Journal of AOAC International, (2018): 101(4), 1199-1204
1National Metrology Institute of Japan


Development of enzyme-linked immunosorbent assay for analysis of total aflatoxins based on monoclonal antibody reactive with aflatoxins B1, B2, G1 and G2

Yamazaki T1, 2, Miyake S2, 3, 4, Sato N, Hirakawa Y1, 2, Iwasa S5, Narita H1, Watanabe T
Food Hyg. Saf. Sci., (2018): 59(5), 200-205
1Kyoto Women’s University
2Advanced Science, Technology & Management Research Institute of Kyoto
3HORIBA, Ltd.
4Azabu University
5Toyohashi University of Tchnology


Intravenous injection of artificial red cells and subsequent dye laser irradiation causes deep vessel impairment in an animal model of port-wine stain

Rikihisa N1, Tominaga M1, Watanabe S2, Mitsukawa N3, Saito Y, Sakai H4
Lasers Med Sci, (2018): 33(6), 1287-1293
1Chiba Rosai Hospital
2Saitama Children’s Medical Center
3Department of Plastic, Reconstructive, and Aesthetic Surgery, Chiba University Graduate School of Medicine
4Department of Chemistry, Nara Medical University


Hatano rats are a suitable metabolic syndrome model for studying feeding behavior, blood pressure levels, and percent body fat

Isobe A1, Shimada T2, 3, Aburada M3, Yanagisawa R4, Sakawa T5, Nakamura T5, Himi TH3, Ohta R, Kawaguchi M1, 3
J. Vet. Med. Sci., (2019): 81 (1), 147-154
1Laboratory of Animal Behavior and Environmental Science, Graduate School of Agriculture, Meiji University
2Department of Hospital Pharmacy, University Hospital, Kanazawa University
3Musashino University
4Center for Health and Environmental Risk Research, National Institute for Environmental Studies
5Faculty of Pharmaceutical Sciences, Teikyo Heisei University


Male Hatano low-avoidance rats show more active sexual behavior with lower plasma testosterone than high-avoidance rats

Nakayama A1, Okawa H2, Zheng M3, 4, Pu S3, 4, Watanabe G3,4,5, Ohta R, Kawaguchi M1, 2
J. Vet. Med. Sci., (2018): 80(7), 1179-1182
1Laboratory of Animal Behavior and Environmental Science, Graduate School of Agriculture, Meiji University
2Laboratory of Animal Behavior and Environmental Science, School of Agriculture, Meiji University
3Department of Basic Veterinary Science, United Graduate School of Veterinary Sciences, Gifu University
4Laboratory of Veterinary Physiology, Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology
5Basic Animal Medicine, Cooperative Division of Veterinary Sciences, Tokyo University of Agriculture and Technology


Transferability and within- and between-laboratory reproducibilities of EpiSensA for predicting skin sensitization potential in vitro: A ring study in three laboratories

Mizumachi H1, Sakuma M2, Ikezumi M, Saito K1、Takeyoshi M2, Imai N2, Okutomi H, Umetsu A, Motohashi H, Watanabe M, Miyazawa M1
J Appl Toxicol (2018): 38(9), 1233-1243
1Kao Corporation, R&D, Safety Science Research
2KOSE Corporation, Research Laboratories


Cause of and countermeasures for oxidation of the cysteine-derived reagent used in the amino acid derivative reactivity assay

Fujita M1, Yamamoto Y1, Watanabe S2, Sugawara T2, Wakabayashi K3, Tahara Y3, Horie N4, Fujimoto K4, Kusakari K5, Kurokawa Y5, Kawakami T6, Kojima K, Kojima H7, Ono A8, Katsuoka Y1, Tanabe H9, Yokoyama H9, Kasahara T1
J Appl Toxicol, (2019): 39(2), 191-208
1Fujifilm Corporation, Safety Evaluation Center
2Lion Corporation, Human & Environmental Safety Evaluation Center
3Mitsui Chemicals, Inc., Chemical Safety Department
4Sumitomo Chemical Co., Ltd., Environmental Health Science Laboratory
5Nissan Chemical Corporation, Biological Research Laboratories
6National Institute of Health Sciences, Division of Environmental Chemistry
7National Institute of Health Sciences, Biological safety Research Center, Division of Risk Assessment
8Okayama University, Graduate school of Medicine, Dentistry and Pharmaceutical sciences, Division of Pharmaceutical Sciences
9Fujifilm Corporation, Research & Development Management Headquarters, Analysis Technology Center, Kanagawa, Japan


Predictive performance and inter-laboratory reproducibility in assessing eye irritation potential of water- and oil-soluble mixtures using the Short Time Exposure test method

Abo T1, 2, Hilberer A3, Behle-Wagner C4, Watanabe M, Cameron D5, Kirst A6, Nukada Y7, Yuki T7, Araki D1, Sakaguchi H7, Itagaki H2
Toxicol In Vitro, (2018): 48, 78-85
1Kao Corporation, Safety Science Research Laboratories, Odawara office
2Faculty of Engineering, Department of Materials Science and Engineering, Yokohama National University
3Institute for In Vitro Sciences, Inc.
4Envigo CRS GmbH
5Kao USA Inc.
6Kao Germany GmbH
7Kao Corporation, Safety Science Research Laboratories, Tochigi plant

ER STTA法:hERα-HeLa-9903細胞を用いたエストロゲン受容体恒常発現系転写活性化試験法の評価報告書

小野 宏、丸野内 棣1, 井口 泰泉2, 小野 敦3
AATEX-JaCVAM, (2017) Vol.6(1), pp.1-27
1藤田保健大学
2基礎生物学研究所
3国立医薬品食品衛生研究所


再構築ヒト角膜様上皮モデル法(Reconstructed Human Cornea-like Epithelium Test Method:RhCE法)の評価報告書

竹内小苗1, 小坂忠司2, 佐々木正治3, 森村智美、吉村 功4
AATEX-JaCVAM, (2017) Vol.6(1), pp.28-36
1P&Gイノベーション合同会社
2残留農薬研究所
3アッヴィ合同会社
4東京理科大学


皮膚感作性試験human Cell Line Activation Test (h-CLAT)の評価報告書

筒井尚久1, 安達玲子2, 金澤由基子, 小島幸一, 佐藤一博3, 武吉正博4, 森本隆史5
AATEX-JaCVAM, (2017) Vol.6(1), pp.37-50
1田辺三菱製薬株式会社
2国立医薬品食品衛生研究所
3国立大学法人福井大学
4一般財団法人化学物質評価研究機構
5住友化学株式会社


生体吸収性材料で求められる生物学的安全性評価

小島幸一
生体吸収性材料の開発と安全性評価(書籍 技術情報協会 東京), (2017): 392-400


医療機器の細胞毒性試験とin vitro遺伝毒性試験

山影康次
バイオマテリアル-生体材料-, (2017): 35, 210-215


Genetic variation in low-dose effects of neonatal DES exposure in female rats

Ohmukai H, Negura T, Tachibana S, Ohta R
Repro. Toxicol., (2017): 73, 322-327


Acute changes in histopathology and intravascular imaging after catheter-based renal denervation in a porcine model

Sakaoka A1, 2, Takami A3, Onimura Y1, Hagiwara H1, Terao H1, Kumagai F, Matsumura K2
Catheter. Cardiovasc. Interv., (2017): 90, 631-638
1 R&D Headquarters, Terumo Corporation
2 Graduate School of Engineering, Osaka Institute of Technology
3 Faculty of Medical Sciences, University of Fukui


Oral mucosal irritatrion study in hamster to evaluate a therapeutic apparatus using hydrogen peroxide photolysis for periodontitis treatment

Niwano Y1, Konno K、Matayoshi T, Nakamura K1, Kanno T1, Sasaki K1
Regul. toxicol. Pharmacol., (2017): 90, 206-213
1 Tohoku University Graduate School of Dentistry


特集:食品製造現場における自主検査と精度管理
食品衛生精度管理比較調査(技能試験)結果の概要
技能試験結果の基本的な考え方

渡辺卓穂
クリーンテクノロジー, Vol. 27, No. 9, 14-18


Permeability of skin to silver nanoparticles after epidermal skin barrier disruption in rats

Kuwagata M, Kumagai F, Saito Y, Higashisaka K1, Yoshioka Y1, 2, Tsutsumi Y1
Funsdam. Toxicol. Sci., (2017): 4 (3), 109-119
1 Laboratory of Toxicology and Safety Science Graduate School of Pharmaceutical Science, Osaka University
2 Vaccine Creation Project, BIKEN Innovative Vaccine Research Alliance Laboratories, Research Institute for Microbial Diseases, Osaka University


Artificial red blood cells as potential photosensitizers in dye laser treatment against port-wine stains

Rikihisa N1, Watanabe S2, Saito Y, Sakai H3
J. Funct. Biomater., (2017): 8 (14): doi:10.3390/jfb8020014
1 Chiba Rosai Hospital
2 Saitama Children's Medical Center
3 Department of chemistry, Nara Medical University


Evaluation of the matrix-like effect in multiresidue pesticide analysis by gas chromatography with tandem mass spectrometry

Akutsu K1, Yoshimitsu M1, Kitagawa Y1, Takatori S1, Fukui N1, Osakada M1, Yamaguchi S1, Kajimura K1, Obana H1, Watanabe T
J. Sep. Sci., (2017): 40 (6), 1298-1300
1 Department of Food, Drugs and Environment, Osaka Prefectural Institute of Public Health


Normal Ovarian Aging, but Modified T-cell Differentiation, in Female Mice following Neonatal Exposure to Bisphenol A

Ohta R, Ohmukai H, Negura T, Tazura Y, Shindo T
Fundam. Toxicol. Sci., (2017): 4 (1): 15-21


Photosensitizer effects of artifical red cells on dye laser irradiation in an animal model assuming port-wine stain treatment

Rikihisa N1, Watanabe S2, Satoh K3, Saito Y, Sakai H4
Plast. Reconstr. Surg.,(2017): 139 (3):707e-716e
1 Chiba Universiy
2 Chiba rosai Hospital
3 Saitama Children's Medical Center
4 Nara Medical University


Correlation between luminescence intensity and cytotoxicity, and usefulness of internal control reporter in cytotoxicity assay using luciferase

Wakuri S, Yamakage K, Kazuki Y1, Kazuki K1, Oshimura M2, Aburatani S3, Yasunaga M4, Nakajima Y1
Anal. Biochem.,(2017): 522 (1):18-29
1 Chromosome Engineering Research Center, Tottori University
2 Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University
3 Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST)
4 Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST)

Thalidomide-induced limb abnormalities in a humanized CYP3A mouse model

Kazuki Y1,2, Akita M3, Kobayashi K4, Osaki M2,5, Satoh D2, Ohta R, Abe S1, Takehara S2, Kazuki K2, Yamazaki H6, Kamataki T7, Oshimura M2
  Sci. Rep.,(2016): 6:21419
1 Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science
2 Chromosome Engineering Research Center (CERC), Tottori University
3 Faculty of Family and Consumer Sciences, Department of Nutrition and Dietetics, Kamakura Women’s University
4 Graduate School of Pharmaceutical Sciences, Chiba University
5 Division of Pathological Biochemistry, Department of Biomedical Sciences, Faculty of Medicine, Tottori University
6 Showa Pharmaceutical University
7 Graduate School of Pharmaceutical Sciences, Hokkaido University


医療機器の生物学的安全性試験

小島幸一
安全性試験の教育・研修テキスト第5版, 安全性試験受託研究機関協議会, (2016)


第3章 外科材料・原料の各種評価と試験, 第4節 癒着防止材などで求められる生物学的安全性評価

小島幸一
手術用シーラント材・癒着防止材の利便化向上を目指した製品開発, 技術情報協会・東京, (2016) pp.221-233


皮膚感作性試験ARE-Nrf2 Luciferase Test Method 角化細胞株レポーターアッセイ評価報告書

筒井尚久1、安達玲子2、金澤由基子、小島幸一、佐藤一博3、武吉正博4、森本隆史5
1 田辺三菱製薬(株)
2 国立医薬品食品衛生研究所
3 国立大学法人福井大学
4 一般財団法人化学物質評価研究機構
5 住友化学(株)
AATEX-JaCVAM, (2016) 5巻, 1号:pp.1-11


眼刺激性試験代替法In Vitro短時間暴露法(Short Time Exposure In Vitro Test Method:STE法)の評価報告書

竹内小苗1, 小坂忠司2, 佐々木正治3, 森村智美, 吉村 功4
1 P&Gイノベーション合同会社
2 残留農薬研究所
3 アッヴィ合同会社
4 東京理科大学
AATEX-JaCVAM, (2016) 5巻、1号:pp.12-21

In vivo comet assay of acrylonitrile, 9-aminoacridine hydrochloride monohydrate and ethanol in rats

Nakagawa Y, Toyoizumi T, Sui H, Ohta R, Kumagai F, Usumi K, Saito Y, Yamakage K
Mutat Res Genet Toxicol Environ Mutagen,(2015): 786-788:104-113


JaCVAM-organized international validation study of the in vivo rodent alkaline comet assay for detection of genotoxic carcinogens: I. Summary of pre-validation study results

Uno Y1, Kojima H21, Omori T3, Corvi R4, Honma M2, Schechtman LM5, Tice RR6, Burlinson B7, Escobar PA8, Kraynak AR9, Nakagawa Y, Nakajima M10, Pant K11, Asano N12, Lovell D13, Morita T2, Ohno Y2, Hayashi M14
Mutat Res Genet Toxicol Environ Mutagen,(2015): 786-788:3-13
1 Mitsubishi Tanabe Pharma Co.
2 National Institute of Health Sciences
3 Kobe University Hospital(formerly Doshisha University, Kyoto)
4 Joint Research Centre of the European Commission
5 Innovative Toxicology Consulting
6 National Institute of Environmental Health Sciences
7 Huntingdon Life Sciences,
8 Boehringer Ingelheim Pharmaceuticals Inc.
9 Merck Research Laboratories
10 University of Shizuoka
11 BioReliance
12 Kinki University
13 St. George’s, University of London
14 Biosafety Research Center, Foods, Drugs and Pesticides


Evaluation of in vivo genotoxicity by thioacetamide in a 28-day repeated-dose liver micronucleus assay using male young adult rats

Sui H, Matsumoto H, Wako Y1, Kawasako K1
Mutat Res Genet Toxicol Environ Mutagen, (2015): 780-781:81-84
1 LSI Medience Corporation


Evaluation of the repeated-dose liver micronucleus assay with p-dimethylaminoazobenzene

Shimada Y1, Sui H, Wako Y2, Kawasako K2
Mutat Res Genet Toxicol Environ Mutagen, (2015): 780-781:56-59
1 Hokko Chemical Industry Co. Ltd.
2 LSI Medience Corporation


II 試験法,第1 章 総論,5 精度管理(内部, 外部),2 外部精度管理

鈴木達也
食品衛生検査指針-微生物編-,(2015): 59-67


重金属を中心とする環境物質の免疫毒性研究とともに

大沢基保
ImmunoTox Letter,(2015): 20:2-4


Immunotoxicity of environmental substances with special reference to heavy metals: Toxicological properties and evaluation - Through with developing immunotoxicology of environmental heavy metals

Ohsawa M
ImmunoTox Letter, (2015): 20:8-9


Modifications of azoxymethane-induced carcinogenesis and 90-day oral toxicities of 2-tetradecylcyclobutanone as a radiolytic product of stearic acid in F344 rats

Sato M1, Todoriki S2, Takahashi T1, Hafez E1, Takasu C1, Uehara H1, Yamakage K, Kondo T3, Matsumoto K4, Furuta M5, Izumi K1
J Toxicol Pathol,(2015): 28:99-107
1 Institute of Health Biosciences, The University of Tokushima Graduate School
2 National Food Research Institute
3 Graduate School of Medicine and Pharmaceutical Science, University of Toyama
4 Kyoto Sangyo University
5 Radiation Research Center, Osaka Prefecture University


Effects of arachidonic acid intake on inflammatory reactions in dextran sodium sulphateinduced colitis in rats

Naito Y1,2, Ji X1,3, Tachibana S, Aoki S, Furuya M, Tazura Y, Miyazawa D4, Harauma A5, Moriguchi T5, Nagata T, Iwai N1, Ohara N4
Br. J. Nutr.,(2015): 114:734-745
1 Department of Genomic Medicine, National Cerebral and Cardiovascular Center
2 Department of Health Science, School of Allied Health Sciences and Graduate School of Medical Sciences, Kitasato University
3 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences
4 College of Pharmacy, Kinjo Gakuin University
5 Department of Food and Life Science, School of Life and Environmental Science, Azabu University


In vitro and in vivo metabolism of N-adamantyl substituted urea-based soluble epoxide hydrolase inhibitors

Liua JY1,2, Tsai HJ1, Morisseau C1, Lango J1, Hwang SH1, Watanabe T, Kim IH1, Hammock BD1
Biochem. Pharmacol.,(2015): 98:718-731
1 Center for Nephrology and Clinical Metabolomics, Division of Nephrology and Rheumatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine
2 2Department of Entomology and Nematology, and UC Davis Comprehensive Cancer Center, University of California, Davis


皮膚感作性試験Direct Peptide Reactivity Assay(DPRA):ペプチド結合性試験評価報告書

筒井尚久1、安達玲子2、金澤由基子、小島幸一、佐藤一博3、武吉正博4、森本隆史5
1 田辺三菱製薬(株)
2 国立医薬品食品衛生研究所
3 国立大学法人福井大学
4 一般財団法人化学物質評価研究機構
5 住友化学(株)
AATEX-JaCVAM, (2015) 4巻, 1号:pp.19-29

Tranexamic acid induces kaolin intake stimulating a pathway involving tachykinin neurokinin 1 receptors in rats

Kakiuchi H1, Kawarai-Shimamura A2, Kuwagata M, Orito K1
Eur. J. Pharmacol., 2014; 723: 1-6
1 Laboratory of Physiology II, Department of Veterinary Medicine, School of Veterinary Medicine, Azabu University
2 Corporate Planning Department, Anicom Holdings, Inc.


Seeking genes responsible for developmental origins of health and disease from the fetal mouse liver following maternal food restriction

Ogawa T1, Shibato J1, Rakwal R1,2,3, Saito T1, Tamura G1, Kuwagata M, Shioda S1
Congenit Anom Kyoto, 2014; 54: 195-219
1 Department of Anatomy, Showa University School of Mediciney
2 Faculty of Life and Environmental Sciences
3 Organization for Educational Initiatives, University of Tsukuba


Ovarian dysfunction, obesity and pituitary tumors in female mice following neonatal exposure to low-dose diethylstilbestrol

Ohta R, Ohmukai H, Toyoizumi T, Shindo T, Marumo H, Ono H
Reprod. Toxicol., 2014; 50: 145-151


Early to middle gestational exposure to diethylstilbestrol impairs the development of labyrinth zone in mouse placenta

Kagawa N1, Saito Y, Nagao T1
Congenit Anom Kyoto, 2014; 54: 116-119
1 Department of Life Science, Kinki University


Trehalose solution protects mesothelium and reduces bowel adhesions

Ohata A1, Tamura N1, Iwata K1, Abe N1, Doi K1, Saito Y, Katoh M2, Nojima H1
J. Surg. Res., 2014; 191: 224-230
1 Naruto Research Institute, Research and Development Center, Otsuka Pharmaceutical Factory, Inc.
2 Study Department, Nihon Bioresearch Inc.


In vitro and in vivo evaluation of hemocompatibility of silk fibroin based artificial vascular grafts

Aytemiz D1, Suzuki Y1, Shindo T, Saotome T1, Tanaka R2, Asakura T1
Int. J. Quant. Chem., 2014; 6: 1-14
1 Department of Biotechnology, Tokyo University of Agriculture and Technology
2 Division of Animal Life Science, Tokyo University of Agriculture and Technology


Development and performance evaluation of a positive reference material for hemolysis testing

Haishima Y1, Hasegawa C1, Nomura Y1, Kawakami T2, Yuba T3, Shindo T, Sakaguchi K4, Tanigawa T4, Inukai K4, Takenouchi M4, Isama K2, Matsuoka A5, Niimi S1
J. Biomed. Mater. Res. Part B Appl. Biomater., 2014; 102: 1809-1816
1 Division of Medical Devices, National Institute of Health Sciences
2 Division of Environmental Chemistry, National Institute of Health Sciences
3 Kawasumi Laboratories, Inc., Corporate Research and Development Division
4 R&D Headquarters, Evaluation Center, TERUMO Corporation
5 Office of Standards and Guidelines Development, Pharmaceuticals and Medical Devices Agency

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